Impact of Contaminating DNA in Whole-Genome Amplification Kits Used for Metagenomic Shotgun Sequencing for Infection Diagnosis
نویسندگان
چکیده
منابع مشابه
Gap statistics for whole genome shotgun DNA sequencing projects
MOTIVATION Investigators utilize gap estimates for DNA sequencing projects. Standard theories assume sequences are independently and identically distributed, leading to appreciable under-prediction of gaps. RESULTS Using a statistical scaling factor and data from 20 representative whole genome shotgun projects, we construct regression equations that relate coverage to a normalized gap measure...
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ژورنال
عنوان ژورنال: Journal of Clinical Microbiology
سال: 2017
ISSN: 0095-1137,1098-660X
DOI: 10.1128/jcm.02402-16